KETAMINE ASSISTED DETOX

Sometimes a slow taper from a substance is not possible or advisable. In those cases, Ketamine has shown potential in the treatment of withdrawal symptoms. Here's a detailed explanation of how ketamine could be useful:

• Neuroplasticity: Ketamine is an NMDA receptor antagonist that modulates glutamate, the brain's primary excitatory neurotransmitter. It promotes neuroplasticity, which is the brain's ability to reorganize and form new neural connections. Substance use can involve long-lasting changes in neural circuits, and ketamine's effects on neuroplasticity may help reverse some of these changes.

• Mood stabilization: Withdrawal often involves persistent mood disturbances such as depression, anxiety, and irritability. Ketamine has rapid-acting antidepressant and anxiolytic effects, which can help alleviate these symptoms. It acts on the brain's glutamate system and increases the production of brain-derived neurotrophic factor (BDNF), a protein that supports the growth and survival of neurons.

• Craving reduction: Withdrawal can also be accompanied by intense drug cravings, which can increase the risk of relapse. Ketamine has been observed to reduce drug cravings and attenuate drug-seeking behavior in preclinical and clinical studies. By modulating glutamate and its associated neural pathways, ketamine may help diminish the intensity of cravings experienced during PAWS.

• Enhanced therapy outcomes: Ketamine-assisted psychotherapy (KAP) is an emerging treatment approach that combines ketamine administration with psychotherapy. Ketamine can help facilitate emotional breakthroughs, enhance introspection, and deepen therapeutic insights. When used in conjunction with therapy, ketamine may aid individuals in processing and resolving the underlying psychological issues contributing to their substance use.